Answer : 3. "449"
Explanation :

Answer: C) 449 Explanation: Given number series is 5  19  49  101  181  295 ? Here the series follows pattern that 5   19   49   101   181   295  ?   14   30   52    80     114   (difference)       16  22   28     34 (difference)          6     6     6  (Common difference)   Therefore, the missing number in the series is ? = 295 + 115 + 34 + 6 = 449.