The most appropriate antonym for the underlined word "blessed" in the given sentence is "cursed." "Blessed" implies being favored, protected, or endowed with divine grace, while "cursed" suggests being subjected to divine displeasure or misfortune. The other options— "appointed" (designated for a specific role), "produced" (created), and "applied" (put into action)— do not convey the opposite meaning of "blessed" in this context.

"Casual" refers to something relaxed, informal, or not strict. The antonym "Formal" denotes something that is official, structured, or follows established conventions. Therefore, option (C) Formal is the opposite or antonym of "Casual."

"Detrimental" means causing harm or damage, so its antonym would be "Harmless," which indicates something that does not cause harm or injury. Therefore, option (B) Harmless is the most suitable antonym in this context.